(BIOMET4D) Smart 4D BIOdegradable METallic Shape-shifting Implants for Dynamic Tissue Restoration

Project details

  • Funding: Horizon Europe. EIC Pathfinder Open 2021 (Project No 101047008)
  • Project coordinator: IMDEA Materials
  • Project period: 01/07/2022 – 30/06/2026

The project


Reconstructive surgeries frequently require multiple, often complex, procedures at a high social and economic cost. A shape-morphing implant that can be implanted using less invasive procedures and that then undergoes predesigned shape changes, leading to tissue expansion and allowing for complete degradation coupled with tissue regeneration, is a radically new treatment concept. 

BIOMET4D aims to create a new generation of shape-shifting and load-bearing implants for dynamic tissue restoration and to introduce a revolutionary paradigm in how actuators can be implemented in biomedicine. Science-towards-technology breakthroughs will be demonstrated with new shape-morphing metamaterials, 4D smart metallic actuators, advanced multi-domain optimization tools, and finally proof-of-concept for two potential clinical applications. Technologically, this vision also goes beyond existing paradigms because of the step-by-step actuation mechanisms, enabled through the additive manufacturing of multi-material degradable metallic structures, that are targeted for an order of magnitude improvement compared to the state-of-the-art. 

A futuristic long-term vision of this breakthrough technology is to dynamically regenerate entire tissues, such as a nose or an ear, and proof-of-concept will be demonstrated for craniosynostosis treatment and skin expansion. This long-term vision can only be achieved through an interdisciplinary approach and will likely have high social and economic impact as well as provide a new line of research for applications of smart metamaterials in medicine and engineering.

Stakeholder Advisory Board

The SAB of the BIOMET4D is a board of experts comitted to the project with the aim of evaluate the progress of the project and to provide advice concerning its potential exploitable results, its dissemination and communication activities, and ethical and regulatory aspects that may influence the expected impact of the project.

  • Ana Mª Zambrano LópezNational Association for Apert Syndrome and Other Syndromic Craniosynostosis (APERTCRAS), Spain
  • Dr. Miguel Ángel Pelaez García – Technical Expert for the Spanish Agency of Medicines and Medical Devices (AEMPS), and Politechnic University of Madrid (UPM) Professor, Spain
  • Frank Reinauer – Head of Production and Innovations Biomaterials of Karl Leibinger Medizintechnik GmbH & co. KG (KLS), Germany
  • Dr. Pedro Martinez Seijas – Oral and Maxillofacial Surgery Department of Santiago de Compostela Universitary Hospital, Spain
  • Dr. Ralf Smeets – Head of Oral and Maxillofacial Department, University Clinics Hamburg-Eppendorf, Germany
  • Dr. Dylan Murray – Craniofacial surgeon, Ireland


Work Team

Dr. Jennifer Patterson / Dr. Jon Molina-Aldareguia / Dr. Javier Llorca / Dr. Pedro Díaz Payno / Dr. Muzi Li
IMDEA Materials

Work team

Dr. Andrés Díaz Lantada / Adrián López Arrabal / William Solórzano Requejo

Work team

Dr. Xiaoshuang Li

Work team

Dr. Ing. Alexander Kopp / Simon Pöstges

Work team

Dr. med. Nadja Kröger

Work team

Dr. Ted Vaughan / Dr. Kevin Moerman

Work team

Prof. Manuel Desco / Dr. Lorena Cussó / Dr. Santiago Ochandino

Funded by

This project has received funding from the EIC Pathfinder under grant agreement No 101047008. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Innovation Council and SMEs Executive Agency (EISMEA). Neither the European Union nor the EISMEA can be held responsible for them