Funding: MSCA Postdoctoral Fellowships 2021. HORIZON-MSCA-2021-PF-01
Project coordinator: IMDEA Materials
Project period: 01/04/2023 – 31/03/2025
IMDEA Materials' researchers
Supervisor: Dra. Jennifer Patterson
Fellow: Pedro José Díaz Payno
Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC can cause underlying bone
damage creating an osteochondral (OC) defect. OC defects cause pain, impaired mobility and can develop to Osteoarthritis (OA). OA is
the most common form of arthritis, affecting nearly 10% of the population worldwide, and a serious disease representing a significant
economic burden to patients and society. In Europe, the cost of OA per patient is estimated to exceed € 10,000 per year. At present,
the treatment options for OA are limited to surgical replacement of the diseased joint with a prosthesis. While this procedure is well
established, it is not without its limitations, and failures are not uncommon. In addition, joint replacement prostheses have a finite lifespan,
making them unsuitable for the growing population of younger and more active patients requiring treatment for OA. While significant
progress has been made in this field, realising an efficacious therapeutic option for the treatment of unresolved OA remains elusive
and is considered to be one of the greatest challenges in the field of orthopaedic regenerative medicine. One of the critical problems
when repairing OC defects is the poor repair of the AC due to its repair with a low-quality scarring tissue, lacking the native aligned
collagen microarchitecture. Therefore, there is a societal need to develop new strategies for AC regeneration.
The RECoil3D project aims to develop a new generation of dynamic load-bearing implants based on the Reinforcement of an extracellular matrix (ECM) derived scaffold containing an aligned pore architecture with a dynamic Coil-shaped 3D printed polylactic acid (PLA) constructs for
AC tissue repair.
Funded by the European Union under Grant Agreement 101110000. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.